What Does Bioavailability Mean?

The proportion of any compound or substance that enters the bloodstream when introduced to the body is known as bioavailability. This value varies due to many factors, the most significant being the method of administration. There are four ways in which substances can enter the bloodstream: inhalation, ingestion, absorption via mucous membranes, and injection. This post outlines what bioavailability means for any compound, including medicines and substances found in food.

Bioavailability Explaining

Intravenously-administered pharmaceuticals have 100% bioavailability because they go straight into the bloodstream. Substances taken orally, on the other hand, have a much longer journey to the bloodstream. Consequently, their bioavailability is lower and more variable, depending on how much the substance interacts with different acids or enzymes in the digestive system and liver. Substances that are inhaled, such as cigarettes or drugs, are absorbed by the alveoli in the lungs, from which they promptly enter the bloodstream and therefore have high bioavailability.

Substances found in food, such as vitamins and minerals, have to undergo a complex process of digestion before they are released into the bloodstream, meaning they have a lower bioavailability than pharmaceuticals.

What is Bioavailability in Nutrition?

Bioavailability in nutrition refers to the amount of a nutrient or compound that is absorbed and utilized by the body after it is consumed. In other words, it is the proportion of the nutrient or compound that enters the bloodstream and becomes available for the body to use. Factors such as food processing, cooking, and individual differences in digestion and metabolism can all affect the bioavailability of nutrients. Understanding bioavailability is important in ensuring that you are getting the most out of the foods you eat and any supplements you take.

What is Sublingual Administration?

Sublingual administration of pharmaceuticals is a process in which medicines are absorbed directly through the sublingual glands located under the tongue. This method of administration is desirable for a number of reasons, one of which being that it is thought to produce a faster rate of absorption and bioavailability than when the pharmaceuticals are ingested.

methods of CBD intake rates of bioavailability Sublingual Administration

The reason for this faster absorption rate is due to a higher rate of blood flow and circulation under the tongue. This allows for a shorter duration of medication time before reaching peak levels of concentration in the body. It also avoids potential reducing metabolites found in the stomach, leading to compromised absorption and bioavailability. Sublingual administration is beneficial for those seeking rapid absorption of medication, such as those suffering from acute symptoms or seeking immediate relief.

Bioavailability is an important factor to consider when choosing a delivery method for any substance, as results may vary on an individual basis. CBD stands out due to its molecular structure, which directly impacts how much of it can be absorbed by the body. Various delivery methods such as inhalation, edibles, and tinctures provide distinct paths to the bloodstream; it’s key to do research before selecting one that’s right for you.

Bioavailability of CBD

CBD products vary widely, from topical creams to edibles. The potency of each method differs dramatically due to bioavailability. For instance, 10 milligrams of CBD inhaled with a vaporizer is not equal to 10 milligrams ingested orally (Pond 1984). This discrepancy is caused by the first pass metabolism effect, which occurs in both the liver and digestive system prior to circulation. Even after taking this into account, the oral bioavailability remains quite low due to other factors.

Due to its lipophilic nature, meaning CBD is attracted to and dissolves in fats and oils, while not being soluble in water. As the human digestive system primarily uses water-based processes, only a minimal percentage of CBD could be absorbed without supplementation from some form of oily molecule. To enhance absorption when ingesting CBD orally, lipid-based absorption enhancers are used or food oils are incorporated. This ensures that more CBD is delivered to the liver for efficient metabolism (Cherniakov 2017).

what is bioavailability in nutrition

Studies have evaluated the range of bioavailability for various CBD delivery methods. Research indicates that oral bioavailability could be between 6-15%, while vaporizing could result in rates up to 50%. Topical and transdermal products have an estimated 45% rate, and nasal sprays can achieve around 40% absorption (Ohlsson 1986, Samara 1988, Paudel 2010). The varied paths of entering the bloodstream result in differing availability levels depending on the product.

To sum up

There are various CBD products, but they don’t all deliver the same metabolites or effects. A 20mg transdermal patch offers more CBD than a 20mg oral capsule, and inhalation with a vaporizer will take effect more quickly than with a cream over a longer period of time. Ultimately, to determine the most suitable method for you, it is important to understand how each option affects your body’s metabolism. It’s essential to consider these differences between CBD products when selecting one that meets your needs.

FAQ About CBD and Bioavailability

What is bioavailability in relation to CBD?

Bioavailability refers to the amount of CBD that actually enters your bloodstream and is available for your body to use.

Why is bioavailability important for CBD?

Bioavailability affects the effectiveness of CBD. Understanding it helps you choose the best delivery method and dosage to ensure you get the most out of your CBD.

What factors affect the bioavailability of CBD?

Factors that affect bioavailability include the delivery method, dosage, and individual differences in metabolism and digestive system.

Which delivery method has the highest bioavailability for CBD?

Inhalation and sublingual absorption have the highest bioavailability for CBD.

What is the bioavailability of oral CBD products?

Oral CBD products like capsules and edibles typically have lower bioavailability than other delivery methods.

Can I increase the bioavailability of my CBD?

Yes, by choosing a delivery method with higher bioavailability, taking CBD with foods that contain healthy fats, or trying new technologies used by some manufacturers.

Does higher bioavailability mean I should take less CBD?

No, dosage is still an important factor.

Are there any risks associated with high bioavailability?

There is no evidence to suggest that high bioavailability of CBD is harmful, but it’s always important to follow recommended dosages and consult with a healthcare professional if you have any concerns or underlying medical conditions.